The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Autoimmune disease-associated CD226 gene variants are not involved in giant cell arteritis susceptibility in the Spanish population.
OBJECTIVES CD226 genetic variants have been associated with a number of autoimmune diseases. The aim of this study was to investigate the potential implication of the CD226 loci in the susceptibility to and main clinical manifestations of giant cell arteritis (GCA). METHODS A Spanish Caucasian cohort of 455 patients diagnosed with biopsy-proven GCA and 1414 healthy controls were included in t...
متن کاملNon-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases.
OBJECTIVES Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in n...
متن کاملGene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis
Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS. Objectives: The present study aimed to evaluate the gene expression of CD226, and its protein serum level in peripheral blood samples of MS patients and healthy individuals. Materials & ...
متن کاملCrohn's associated NOD2 gene variants are not involved in determining susceptibility to multiple sclerosis.
Crohn's associated NOD2 gene variants are not involved in determining susceptibility to multiple sclerosis Autoimmune diseases, such as multiple sclerosis and Crohn's disease, are believed to result from the effects of environmental agents acting on genetically susceptible individuals. Evidence from segregation analysis and systematic whole genome linkage studies indicates that the nature of th...
متن کاملTERT gene harbors multiple variants associated with pancreatic cancer susceptibility.
A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT-CLPTM1L gene region on chromosome 5p15.33. Because this region is characterized by low linkage disequilibrium, we sought to identify whether additional single nucleotide polymorphisms (SNPs) could be related to pancreatic cancer risk, independently of rs401681....
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2010
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2010.30